CBD for Well-being
GPR55

Studies indicate that CBD functions as an antagonist that blocks, or deactivates, another G protein-coupled receptor known as GPR55. It is involved in modulating blood pressure and bone density, among other processes.

GPR55 promotes osteoclast cell function, which facilitates bone reabsorption. Hyperactive GPR55 receptor signaling is associated with osteoporosis.

GPR55, when activated, also promotes cancer cell proliferation, according to a 2010 study by researchers at the Chinese Academy of Sciences in Shanghai. This receptor is expressed in various types of cancer.

CBD is a GPR55 antagonist, as University of Aberdeen scientist Ruth Ross disclosed at the 2010 conference of the International Cannabinoid Research Society in Lund, Sweden. By blocking GPR55 signaling, CBD may decrease both bone reabsorption and cancer cell proliferation.

Anatomy Drawing
PPAR
Image by Deniz Altindas

CBD also may have an anti-cancer effect by activating  peroxisome proliferator activated receptors (PPARs). Activation of the receptor known as PPAR-gamma has an anti-proliferative effect as well as an ability to induce tumor regression in human lung cancer cell lines. PPAR-gamma activation degrades amyloid-beta plaque, a key molecule linked to the development of Alzheimer’s disease. This is one of the reasons why cannabidiol, a PPAR-gamma agonist, may be a useful remedy for Alzheimer’s patients.

PPAR receptors also regulate genes that are involved in energy homeostasis, lipid uptake, insulin sensitivity, and other metabolic functions. Diabetics may benefit from a CBD-rich treatment regimen because of this.

According to a team of Stony Brook University scientists, CBD functions as an anandamide reuptake and breakdown inhibitor, thereby raising natural levels in the brain. Enhancing endocannabinod tone via reuptake inhibition may be a key mechanism whereby CBD bestows neuroprotective effects against seizures, as well as many other health benefits.

CBD’s anti-inflammatory and anti-anxiety effects are in part attributable to its inhibition of adenosine reuptake. A1A and A2A adenosine receptors play significant roles in cardiovascular function, regulating caradiac oxygen consumption and blood flow. These receptors have anti-inflammatory effects.

These people were skeptical about what CBD could do for them!
Image by Juno Jo

Latrice, Fashion Designer

There are so many unnescessary supplements out there. Our bodies can litteraly produce some of the chemicals we need for survival. Before hemp prohibition people were able to get cannabinoids like CBD from the meat that they ate because hemp feed was common. People were healthier back then. I use this product regularly due to all the benefits hemp offers!

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Chelsea, Flight Attendant

Self-care is so important. That's why I use CBD. The science is already available. We just need the FDA to hurry up and approve what we have already known for thousands of years, that hemp is medicine!

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Michael, Physical Therapist

I reccomend this product to all of my clients and the feedback is always great. It helps me introduce them to a natural alternative for their pain. Plant medicines are crucial for our over all well-being.

If you want to continue feeling the way you do we totally get it, not everyone wants to change.
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